The Utility of Metformin in the Management of Metabolic Syndrome Induced by Atypical Antipsychotics

Authors

DOI:

https://doi.org/10.46570/utjms-2026-1676

Keywords:

antipsychotics, metabolic syndrome, Metformin

References

Jesus, C., Jesus, I., & Agius, M. (2015). A review of the evidence for the use of Metformin in the treatment of metabolic syndrome caused by antipsychotics. Psychiatria Danubina, 27 Suppl 1, S489–S491.

Rojo, L. E., Gaspar, P. A., Silva, H., Risco, L., Arena, P., Cubillos-Robles, K., & Jara, B. (2015). Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacological research, 101, 74–85. https://doi.org/10.1016/j.phrs.2015.07.022

Akinola, P. S., Tardif, I., & Leclerc, J. (2023). Antipsychotic-Induced Metabolic Syndrome: A Review. Metabolic syndrome and related disorders, 21(6), 294–305. https://doi.org/10.1089/met.2023.0003

Au, E., Panganiban, K. J., Wu, S., Sun, K., Humber, B., Remington, G., Agarwal, S. M., Giacca, A., Pereira, S., & Hahn, M. (2025). Antipsychotic-Induced Dysregulation of Glucose Metabolism Through the Central Nervous System: A Scoping Review of Animal Models. Biological psychiatry. Cognitive neuroscience and neuroimaging, 10(3), 244–257. https://doi.org/10.1016/j.bpsc.2024.10.001

Manta, A., Georganta, A., Roumpou, A., Zoumpourlis, V., Spandidos, D. A., Rizos, E., & Peppa, M. (2025). Metabolic syndrome in patients with schizophrenia: Underlying mechanisms and therapeutic approaches (Review). Molecular medicine reports, 31(5), 114. https://doi.org/10.3892/mmr.2025.13479

Wu, R. R., Zhao, J. P., Guo, X. F., He, Y. Q., Fang, M. S., Guo, W. B., Chen, J. D., & Li, L. H. (2008). Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study. The American journal of psychiatry, 165(3), 352–358. https://doi.org/10.1176/appi.ajp.2007.07010079

Yu, O., Lu, M., Lai, T. K. Y., Hahn, M., Agarwal, S. M., O'Donoghue, B., Ebdrup, B. H., & Siskind, D. (2024). Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis. Therapeutic advances in psychopharmacology, 14, 20451253241255476. https://doi.org/10.1177/20451253241255476

de Silva, V. A., Suraweera, C., Ratnatunga, S. S., Dayabandara, M., Wanniarachchi, N., & Hanwella, R. (2016). Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis. BMC psychiatry, 16(1), 341. https://doi.org/10.1186/s12888-016-1049-5

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Published

2026-02-17

How to Cite

1.
Desai S, Aftab F, Razoky S. The Utility of Metformin in the Management of Metabolic Syndrome Induced by Atypical Antipsychotics. Translation [Internet]. 2026 Feb. 17 [cited 2026 Feb. 17];15(S1). Available from: https://openjournals.utoledo.edu/index.php/translation/article/view/1676

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Section

Perspectives in Psychiatry: A Learner’s Viewpoint