Using iLINCS to mine for Oxytocin signature to find new drug candidates or molecular pathways that can be used for future treatment for autism

Authors

DOI:

https://doi.org/10.46570/utjms-2025-1486

Keywords:

Autism, ASD, aspergers, Oxytocin, psychoneuroendocrinology

Author Biography

Elissar Andari, University of Toledo

Assisant Professor - Department of Neurosciences and Psychiatry

References

Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U A. 2010;107(9):4389-4394. doi:10.1073/pnas.0910249107

Guastella AJ, Hickie IB. Oxytocin Treatment, Circuitry, and Autism: A Critical Review of the Literature Placing Oxytocin Into the Autism Context. Biol Psychiatry. 2016;79(3):234-242. doi:10.1016/j.biopsych.2015.06.028

Young LJ, Wang Z. The neurobiology of pair bonding. Nat Neurosci. 2004;7(10):1048-1054. doi:10.1038/nn1327

Janz P, Knoflach F, Bleicher K, et al. Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats. Front Cell Neurosci. 2023;17:1286552. doi:10.3389/fncel.2023.1286552

Nishimura H, Yoshimura M, Shimizu M, et al. Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats. Commun Biol. 2022;5(1):907. doi:10.1038/s42003-022-03879-8

Wasserman AH, Huang AR, Lewis-Israeli YR, et al. Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury. Front Cell Dev Biol. 2022;10:985298. doi:10.3389/fcell.2022.985298

Xie Z, Kropiwnicki E, Wojciechowicz ML, et al. Getting Started with LINCS Datasets and Tools. Curr Protoc. 2022;2(7):e487. doi:10.1002/cpz1.487

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Published

2025-10-15

How to Cite

1.
Vento C (Gabby), Andari E. Using iLINCS to mine for Oxytocin signature to find new drug candidates or molecular pathways that can be used for future treatment for autism . Translation [Internet]. 2025 Oct. 15 [cited 2025 Oct. 18];14(S1). Available from: https://openjournals.utoledo.edu/index.php/translation/article/view/1486

Issue

Vol. 14 No. S1 (2025): 2025 Department of Neurosciences and Psychiatry Symposium

Section

Departments of Neuroscience and Psychiatry Research Symposium

License

Copyright (c) 2025 Gabby, Elissar Andari (Author)

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