TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review.
TANGO-2
DOI:
https://doi.org/10.46570/utjms.vol7-2020-389Keywords:
TANGO-2, Rhabdomyolysis, creatinine kinaseAbstract
We report a unique case of prolonged acute rhabdomyolysis in a 2-year-old male with known TANGO-2 mutation with delayed peak in creatinine kinase levels secondary to human metapneumovirus infection. Creatinine kinase peaked at 424,760 U/l on day 9 of hospitalization. Resolution of rhabdomyolysis was achieved using aggressive management with intravenous fluids with optimal urine output and no kidney injury. TANGO-2 patients may develop severe and prolonged rhabdomyolysis with a delayed peak suggesting the need for prolonged inpatient hospitalization to prevent life-threatening complications.
References
1. Seema R Lalani, MD, Brett Graham, MD, PhD, Lindsay Burrage, MD, PhD, Yi-Chen Lai, MD, Fernando Scaglia, MD, Claudia Soler-Alfonso, MD, Christina Miyake, MD, MS, and Yaping Yang, PhD.TANGO2-Related Metabolic Encephalopathy and Arrhythmias. Gene reviews. December 2018.
2. Elsayed E1, Reilly RF.Rhabdomyolysis: a review, with emphasis on the pediatric population.Pediatr Nephrol. 2010 Jan;25(1):7-18. doi: 10.1007/s00467-009-1223-9.
3. Lalani SR, Liu P, Rosenfeld JA, et al. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. Am J Hum Genet. 2016;98(2):347–357. doi:10.1016/j.ajhg.2015.12.008
4. F. Ricci, R. Scalco, T. Mongini, G. Ferrero, A. Manole, E. Bertini, M. Desikan, I. Moroni, M. Di Rocco, H. Jungbluth, R. Quinlivan, H. Houlden. Multi-system disorder and severe recurrent rhabdomyolysis due to TANGO2 mutations in a 3 year-old child. Neuromuscular disorders. October 2017Volume 27, Supplement 2, Page S207
5. Scalco RS, Gardiner AR, Pitceathly RD, et al. Rhabdomyolysis: a genetic perspective. Orphanet J Rare Dis. 2015;10:51. Published 2015 May 2. doi:10.1186/s13023-015-0264-3
6. de Meijer A.R., Fikkers B.G., de Keijzer M.H., van Engelen B.G., Drenth J.P. Serum creatine kinase as predictor of clinical course in rhabdomyolysis: a 5-year intensive care survey. Intensive Care Med. 2003;29:1121–1125.
7. Dines, J.N., Golden-Grant, K., LaCroix, A. et al. TANGO2: expanding the clinical phenotype and spectrum of pathogenic variants. Genet Med 21, 601–607 (2019). https://doi.org/10.1038/s41436-018-0137-y
8. James Williams, MBBCh FRCA FFICM, Chris Thorpe, MBBS FRCA FFICM, Rhabdomyolysis, Continuing Education in Anaesthesia Critical Care & Pain, Volume 14, Issue 4, August 2014, Pages 163–166,https://doi.org/10.1093/bjaceaccp/mkt051
9. Chavez, L.O., Leon, M., Einav, S. et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit Care 20, 135 (2016). https://doi.org/10.1186/s13054-016-1314-5
10. Chen CY, Lin YR, Zhao LL, et al. Clinical spectrum of rhabdomyolysis presented to pediatric emergency department. BMC Pediatr. 2013;13:134. Published 2013 Sep 3. doi:10.1186/1471-2431-13-134
11. Cervellin G, Comelli I, Benatti M, Sanchis-Gomar F, Bassi A, Lippi G.Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.Clin Biochem. 2017 Aug;50(12):656-662. Epub 2017 Feb 21.doi: 10.1016/j.clinbiochem.2017.02.016.
12. Attanasi M, Petrosino MI, Guidone PI, et al. A pediatric case of rhabdomyolysis with acute renal failure due to co-infection with Epstein-Barr virus and Human herpesvirus 6. Arch Med Sci. 2018;14(1):254–256. doi:10.5114/aoms.2016.61352
13. Barbara M. Goldsmith and Jocelyn M. Hicks. Rhabdomyolysis: Two Pediatric Case ReportsCLIN. CHEM. 31/2, 314-317 (1985) 314 CLINICAL CHEMISTRY, Vol. 31, No. 2, 1985
14. Basheer, N., Mneimneh, S., & Rajab, M. (2017). Seven-Digit Creatine Kinase in Acute Rhabdomyolysis in a Child. Child Neurology Open. https://doi.org/10.1177/2329048X16684396
2. Elsayed E1, Reilly RF.Rhabdomyolysis: a review, with emphasis on the pediatric population.Pediatr Nephrol. 2010 Jan;25(1):7-18. doi: 10.1007/s00467-009-1223-9.
3. Lalani SR, Liu P, Rosenfeld JA, et al. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. Am J Hum Genet. 2016;98(2):347–357. doi:10.1016/j.ajhg.2015.12.008
4. F. Ricci, R. Scalco, T. Mongini, G. Ferrero, A. Manole, E. Bertini, M. Desikan, I. Moroni, M. Di Rocco, H. Jungbluth, R. Quinlivan, H. Houlden. Multi-system disorder and severe recurrent rhabdomyolysis due to TANGO2 mutations in a 3 year-old child. Neuromuscular disorders. October 2017Volume 27, Supplement 2, Page S207
5. Scalco RS, Gardiner AR, Pitceathly RD, et al. Rhabdomyolysis: a genetic perspective. Orphanet J Rare Dis. 2015;10:51. Published 2015 May 2. doi:10.1186/s13023-015-0264-3
6. de Meijer A.R., Fikkers B.G., de Keijzer M.H., van Engelen B.G., Drenth J.P. Serum creatine kinase as predictor of clinical course in rhabdomyolysis: a 5-year intensive care survey. Intensive Care Med. 2003;29:1121–1125.
7. Dines, J.N., Golden-Grant, K., LaCroix, A. et al. TANGO2: expanding the clinical phenotype and spectrum of pathogenic variants. Genet Med 21, 601–607 (2019). https://doi.org/10.1038/s41436-018-0137-y
8. James Williams, MBBCh FRCA FFICM, Chris Thorpe, MBBS FRCA FFICM, Rhabdomyolysis, Continuing Education in Anaesthesia Critical Care & Pain, Volume 14, Issue 4, August 2014, Pages 163–166,https://doi.org/10.1093/bjaceaccp/mkt051
9. Chavez, L.O., Leon, M., Einav, S. et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit Care 20, 135 (2016). https://doi.org/10.1186/s13054-016-1314-5
10. Chen CY, Lin YR, Zhao LL, et al. Clinical spectrum of rhabdomyolysis presented to pediatric emergency department. BMC Pediatr. 2013;13:134. Published 2013 Sep 3. doi:10.1186/1471-2431-13-134
11. Cervellin G, Comelli I, Benatti M, Sanchis-Gomar F, Bassi A, Lippi G.Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.Clin Biochem. 2017 Aug;50(12):656-662. Epub 2017 Feb 21.doi: 10.1016/j.clinbiochem.2017.02.016.
12. Attanasi M, Petrosino MI, Guidone PI, et al. A pediatric case of rhabdomyolysis with acute renal failure due to co-infection with Epstein-Barr virus and Human herpesvirus 6. Arch Med Sci. 2018;14(1):254–256. doi:10.5114/aoms.2016.61352
13. Barbara M. Goldsmith and Jocelyn M. Hicks. Rhabdomyolysis: Two Pediatric Case ReportsCLIN. CHEM. 31/2, 314-317 (1985) 314 CLINICAL CHEMISTRY, Vol. 31, No. 2, 1985
14. Basheer, N., Mneimneh, S., & Rajab, M. (2017). Seven-Digit Creatine Kinase in Acute Rhabdomyolysis in a Child. Child Neurology Open. https://doi.org/10.1177/2329048X16684396
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Published
2020-08-13
How to Cite
Kheireldin, R., Imdad, S., & Ostwani, W. (2020). TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review. : TANGO-2. Translation: The University of Toledo Journal of Medical Sciences, 7, 24–27. https://doi.org/10.46570/utjms.vol7-2020-389
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