Metastatic Breast Cancer to the Bladder
DOI:
https://doi.org/10.46570/utjms.vol7-2020-332Abstract
Metastatic breast cancer to the bladder is extraordinarily rare, with only 66 cases reported in the literature to date. Occasionally, metastatic breast cancer can first present itself with obstructive uropathy from a proposed retroperitoneal spread. We present a case of in which a 77 year old Caucasian female was found to have acute urinary obstruction from metastatic breast cancer to the bladder. Her breast biopsy came back invasive carcinoma with lobular features (Estrogen Receptor negative, Progesterone Receptor negative, and HER2 negative). She has symptoms of spontaneous urinary incontinence, but no gross hematuria. She had elevated Chromogranin A, Cancer Antigen (CA) 19-9, and CEA. She had a bladder biopsy which demonstrated metastatic breast carcinoma that stained GATA3, GCDFP15, BerEp4 positive and CK20 negative. 0% of tumor cells were positive for PD-L1 expression. The patient had renal deterioration despite bilateral ureteral stent placement, and thus required percutaneous nephrostomy tube placement. She died 4 months after her initial diagnosis.
References
Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108. DOI: https://doi.org/10.3322/caac.21262
U.S. Cancer Statistics Working Group. U.S. Cancer Statistics Data Visualizations Tool boNsd-USDoHaH.
Sant M, Eurocare Working G. Differences in stage and therapy for breast cancer across Europe. Int J Cancer. 2001;93(6):894-901. DOI: https://doi.org/10.1002/ijc.1408
Sant M, Allemani C, Berrino F, et al. Breast carcinoma survival in Europe and the United States. Cancer. 2004;100(4):715-722. DOI: https://doi.org/10.1002/cncr.20038
Tejler G, Norberg B, Dufmats M, et al. South East Sweden Breast Cancer G. Survival after treatment for breast cancer in a geographically defined population. Br J Surg. 2004;91(10):1307-1312. DOI: https://doi.org/10.1002/bjs.4697
Ernst MF, Voogd AC, Coebergh JW, et al. Breast carcinoma diagnosis, treatment, and prognosis before and after the introduction of mass mammographic screening. Cancer. 2004;100(7):1337-1344. DOI: https://doi.org/10.1002/cncr.20139
Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993;114(4):637-641; discussion 641-632.
Arpino G, Bardou VJ, Clark GM, et al. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004;6(3):R149-156. DOI: https://doi.org/10.1186/bcr767
Bates AW, Baithun SI. The significance of secondary neoplasms of the urinary and male genital tract. Virchows Arch. 2002;440(6):640-647. DOI: https://doi.org/10.1007/s00428-001-0549-x
Bates AW, Baithun SI. Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: clinicopathological and histological features of 282 cases. Histopathology. 2000;36(1):32-40. DOI: https://doi.org/10.1046/j.1365-2559.2000.00797.x
Abrams HL, Spiro R, Goldstein N. Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer. 1950;3(1):74-85. DOI: https://doi.org/10.1002/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7
Pontes JE, Oldford JR. Metastatic breast carcinoma to the bladder. J Urol. 1970;104(6):839-842. DOI: https://doi.org/10.1016/S0022-5347(17)61848-2
Goldstein AG. Metastatic carcinoma to the bladder. J Urol. 1967;98(2):209-215. DOI: https://doi.org/10.1016/S0022-5347(17)62857-X
Hagemeister FB, Jr., Buzdar AU, Luna MA, et al. Causes of death in breast cancer: a clinicopathologic study. Cancer. 1980;46(1):162-167. DOI: https://doi.org/10.1002/1097-0142(19800701)46:1<162::AID-CNCR2820460127>3.0.CO;2-B
Kase AM, Menke D, Tan W. Breast cancer metastasis to the bladder: a literature review. BMJ Case Rep. 2018;2018. DOI: https://doi.org/10.1136/bcr-2017-222031
Wang G, Zhou C, Conklin C, et al. Metastatic breast carcinoma to the urinary bladder-a report of 11 cases including a tumor to tumor metastasis. Virchows Arch. 2019. DOI: https://doi.org/10.1007/s00428-018-02515-3
Feldman PA, Madeb R, Naroditsky I, et al. Metastatic breast cancer to the bladder: a diagnostic challenge and review of the literature. Urology. 2002;59(1):138. DOI: https://doi.org/10.1016/S0090-4295(01)01489-3
Soon PS, Lynch W, Schwartz P. Breast cancer presenting initially with urinary incontinence: a case of bladder metastasis from breast cancer. Breast. 2004;13(1):69-71. DOI: https://doi.org/10.1016/j.breast.2003.09.005
Mairy Y, Opsomer R, Donnez J, et al. [Bladder metastases from breast cancer: 2 cases]. Acta Urol Belg. 1982;50(1):87-90.
Shah KG, Modi PR, Rizvi J. Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure. Indian J Urol. 2011;27(1):135-136. DOI: https://doi.org/10.4103/0970-1591.78421
Xiao GQ, Chow J, Unger PD. Metastatic tumors to the urinary bladder: clinicopathologic study of 11 cases. Int J Surg Pathol. 2012;20(4):342-348. DOI: https://doi.org/10.1177/1066896911428736
Luczynska E, Pawlik T, Chwalibog A, et al. Metastatic Breast Cancer to the Bladder case report and review of literature. J Radiol Case Rep. 2010;4(5):19-26. DOI: https://doi.org/10.3941/jrcr.v4i5.395
Massoud W, Ferlicot S, Hajj P, et al. Metastatic breast carcinoma to the bladder. Urology. 2009;74(4):785-786. DOI: https://doi.org/10.1016/j.urology.2009.02.008
Forster J, Agrawal V, Anathhanam AJ, et al. Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. Urol Oncol. 2006;24(1):33-35. DOI: https://doi.org/10.1016/j.urolonc.2005.07.012
Grabstald H, Kaufman R. Hydronephrosis secondary to ureteral obstruction by metastatic breast cancer. J Urol. 1969;102(5):569-576. DOI: https://doi.org/10.1016/S0022-5347(17)62202-X
Silverstein LI, Plaine L, Davis JE, et al. Breast carcinoma metastatic to bladder. Urology. 1987;29(5):544-547. DOI: https://doi.org/10.1016/0090-4295(87)90048-3
Wong MH, Yiu MK, Ho KL. Metastatic carcinoma of breast in the urinary bladder. Hong Kong Med J. 2013;19(5):455-457. DOI: https://doi.org/10.12809/hkmj133768
Cetin K, Christiansen CF, Svaerke C, et al. Survival in patients with breast cancer with bone metastasis: a Danish population-based cohort study on the prognostic impact of initial stage of disease at breast cancer diagnosis and length of the bone metastasis-free interval. BMJ Open. 2015;5(4):e007702. DOI: https://doi.org/10.1136/bmjopen-2015-007702
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
