Pre-eclampsia and the Risk of Development of Psychiatric Disorders
DOI:
https://doi.org/10.46570/utjms-2026-1684Keywords:
psychosis, PTSD, preeclampsiaAbstract
Pre-eclampsia (PE) is a severe disease of pregnancy occurring most often around 20 weeks gestation and marked by symptoms of new-onset hypertension, proteinuria, and end organ damage. Given its high prevalence and serious risk in causing complications, it is important to understand the etiology and potential outcomes of PE. Emerging research suggests that PE during pregnancy may be associated with an increased risk of severe psychiatric disorders in the mother. In this study, we aim to review the current literature examining whether women with PE are more likely to develop subsequent psychiatric disorders including psychosis, mania, and PTSD.
References
Karrar SA, Martingano DJ, Hong PL. Preeclampsia. Treasure Island (FL); 2024.
Lin D, Chen Y. Maternal Depression and Preeclampsia Effects on the Maternal and Offspring's Mental and Physical Health. Heart and Mind 6(1): p 16-21, Jan–Mar 2022.
Dutsch-Wicherek MM, Lewandowska A, Zgliczynska M, Szubert S, Lew-Starowicz M. Psychiatric disorders and changes in immune response in labor and postpartum. Front. Biosci. (Landmark Ed) 2020, 25(8), 1433–1461.
Bergink V, Laursen TM, Johannsen BMW, Kushner SA, Meltzer-Brody S, Munk-Olsen T. Pre-eclampsia, and first-onset postpartum psychiatric episodes: a Danish population-based cohort study. Psychol Med. 2015 Aug 5;45(16):3481–3489.
Meltzer-Brody S, Maegbaek ML, Medland SE, Miller WC, Sullivan P, Munk-Olsen T. Obstetrical, pregnancy and socio-economic predictors for new onset severe postpartum psychiatric disorders in primiparous. women. Psychol Med. 2017 June; 47(8): 1427–1441.
Moy M, Truonghuynh A, Villarreal E, Neal D. Antepartum Psychosis in the Setting of Preeclampsia with Severe Features: A Case Report. Cureus. 2023 Nov 29;15(11): e49678.
Porcel J, Feigal C, Poye L, Postma IR, Zeeman GG, Olowoyeye A, Tsigas E, Wilson M. Hypertensive disorders of pregnancy and risk of screening positive for Posttraumatic Stress Disorder: A cross-sectional study. Pregnancy Hypertension. 2013 Oct;3(4):254-60.
Roberts L, Davis GK and Homer CSE (2019) Depression, Anxiety, and Post-traumatic Stress Disorder Following a Hypertensive Disorder of Pregnancy: A Narrative Literature Review. Front. Cardiovasc. Med. 6:147. doi: 10.3389/fcvm.2019.00147
Roberts L, Henry A, Harvey SB, Homer CSE, Davis GK. Depression, anxiety and posttraumatic stress disorder six months following preeclampsia and normotensive pregnancy: a P4 study. BMC Pregnancy Childbirth. 2022; 22:108.
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Copyright (c) 2026 Sabrina Khuder, Nithara Murthy, Mirlinda Elmazi, Navtej Mann (Author)

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