Access to Psychiatric Medications in Unhoused Populations: Implications for Hospitalization and Readmission Rates
DOI:
https://doi.org/10.46570/utjms-2026-1673Keywords:
Psychiatry, Unhoused, Medication AdherenceAbstract
Persons experiencing homelessness (PEH) face disproportionately high rates of psychiatric illness and hospitalization, with mental illness prevalence reported as high as 76.2%—significantly higher than in the general population. Psychiatric treatment for PEH is often hindered by systemic barriers to care, including medication nonadherence stemming from fragmented healthcare delivery, stigma, transportation challenges, and unstable housing. This discontinuity contributes to elevated readmission rates, with studies showing 30-day psychiatric readmission rates up to 2.04 times higher for unhoused individuals. Medication access is further complicated by inappropriate prescribing patterns and difficulty in maintaining treatment regimens for chronic mental illnesses such as schizophrenia and bipolar disorder. Multifactorial barriers—spanning patient-level, treatment-related, and structural factors—worsen adherence. Evidence-based interventions such as Assertive Community Treatment, Customized Adherence Enhancement with long-acting injectables, and Housing First models have shown success in improving treatment continuity and reducing psychiatric symptomatology. Emerging solutions like street medicine and mobile outreach deliver low-barrier care directly to shelters and encampments. Addressing psychiatric medication adherence among PEH is not only a clinical priority but a public health imperative, requiring integrated, compassionate, and housing-informed care models.
References
Gutwinski, S., et al., The prevalence of mental disorders among homeless people in high-income countries: An updated systematic review and meta-regression analysis. PLoS Med, 2021. 18(8): p. e1003750.
Russolillo, A., et al., Association of homelessness and psychiatric hospital readmission-a retrospective cohort study 2016-2020. BMC Psychiatry, 2023. 23(1): p. 459.
Saab, D., et al., Hospital Readmissions in a Community-based Sample of Homeless Adults: a Matched-cohort Study. J Gen Intern Med, 2016. 31(9): p. 1011-8.
Subedi, K., B. Acharya, and S. Ghimire, Factors Associated With Hospital Readmission Among Patients Experiencing Homelessness. Am J Prev Med, 2022. 63(3): p. 362-370.
Fond, G., et al., Prescription of potentially inappropriate psychotropic drugs in homeless people with schizophrenia and bipolar disorders. Results from the French Housing First (FHF) program. Prog Neuropsychopharmacol Biol Psychiatry, 2019. 89: p. 84-89.
Coe, A.B., et al., Medication adherence challenges among patients experiencing homelessness in a behavioral health clinic. Res Social Adm Pharm, 2015. 11(3): p. e110-20.
Rezansoff, S.N., et al., Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: a 15-year retrospective cohort study. Soc Psychiatry Psychiatr Epidemiol, 2016. 51(12): p. 1623-1632.
Stergiopoulos, V., et al., Collaborative mental health care for the homeless: the role of psychiatry in positive housing and mental health outcomes. Can J Psychiatry, 2008. 53(1): p. 61-7.
Hird, R., R. Radhakrishnan, and J. Tsai, A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders. Front Psychiatry, 2023. 14: p. 1339801.
Su, K.Y., et al., Behavioral Health Care Delivery Through Street Medicine Programs in California. Community Ment Health J, 2024. 60(2): p. 283-291.
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Copyright (c) 2026 Peyton Roth, Tarak Davuluri, Hunter Eby (Author)

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