Asymmetry in Parkinson’s Disease: Exploring the Role of Hemispheric Specialization in Treatment Success

Authors

  • Dipesh Pokharel The University of Toledo College of Medicine and Life Science, Department of Neurosciences/Neurology https://orcid.org/0000-0002-3593-3367
  • Caroline Swain The University of Toledo College of Medicine and Life Science Department of Neurosciences/Neurology
  • Dilshan Beligala Department of Neurology, The university of Toledo https://orcid.org/0000-0002-3760-4479
  • Isable Nester Department of Neurology, The University of Toledo https://orcid.org/0009-0009-9141-974X
  • Khoi Le Department of Neurology, The University of Toledo
  • Vaibhavi Peshattiwar Department of Neurology, The University of Toledo
  • Kala Venkiteswaran Department of Neurology/Neurosciences, The University of Toledo
  • Thyagarajan Subramanian Department of Neurosciences,Neurology and Bioengineering, The University of Toledo

DOI:

https://doi.org/10.46570/utjms-2025-1475

Keywords:

Limb Dominance, Hemisperic dominance, Hemispheric lateralization, Parkinson's Disease, Hemispheric specialization, Handedness, Pawedness

References

Li, P., Ensink, E., Lang, S., Marshall, L., Schilthuis, M., Lamp, J., Vega, I., & Labrie, V. (2020). Hemispheric asymmetry in the human brain and in Parkinson's disease is linked to divergent epigenetic patterns in neurons. Genome biology, 21(1), 61. https://doi.org/10.1186/s13059-020-01960-1

Pagano, G., Ferrara, N., Brooks, D. J., & Pavese, N. (2016). Age at onset and Parkinson's disease phenotype. Neurology, 86(15), 1400–1407. https://doi.org/10.1212/WNL.0000000000002461

Wang, J., Yang, Q. X., Sun, X., Vesek, J., Mosher, Z., Vasavada, M., Chu, J., Kanekar, S., Shivkumar, V., Venkiteswaran, K., & Subramanian, T. (2015). MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease. Parkinsonism & related disorders, 21(6), 590–596. https://doi.org/10.1016/j.parkreldis.2015.03.012

Pençe S. (2002). Paw preference in rats. Journal of basic and clinical physiology and pharmacology, 13(1), 41–49. https://doi.org/10.1515/jbcpp.2002.13.1.41

Nikkhah, G., Falkenstein, G., & Rosenthal, C. (2001). Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance. The Journal of neuroscience: the official journal of the Society for Neuroscience, 21(16), 6252–6263. https://doi.org/10.1523/JNEUROSCI.21-16-06252.2001

Downloads

Published

2025-10-15

How to Cite

1.
Pokharel D, Swain C, Beligala D, Nester I, Le K, Peshattiwar V, Venkiteswaran K, Subramanian T. Asymmetry in Parkinson’s Disease: Exploring the Role of Hemispheric Specialization in Treatment Success. Translation [Internet]. 2025 Oct. 15 [cited 2025 Oct. 18];14(S1). Available from: https://openjournals.utoledo.edu/index.php/translation/article/view/1475

Issue

Vol. 14 No. S1 (2025): 2025 Department of Neurosciences and Psychiatry Symposium

Section

Departments of Neuroscience and Psychiatry Research Symposium

License

Copyright (c) 2025 Dipesh Pokharel, Caroline Swain , Dilshan Beligala, Isable Nester , Khoi Le , Vaibhavi Peshattiwar, Kala Venkiteswaran , Thyagarajan Subramanian (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)