A Rare Case of Post-Radiation Angiosarcoma with Pleural Metastasis
DOI:
https://doi.org/10.46570/utjms-2026-1324Keywords:
Angiosarcoma, pleural metastsis, breast cancerAbstract
Soft tissue sarcomas (STS) represent 1% of all malignancies in adults. Angiosarcomas are an uncommon subtype of vascular or lymphatic origin, compromising 2% of STS. We present a rare case of secondary angiosarcoma of the breast. Following treatment for invasive ductal carcinoma and subsequent diagnosis of radiation-induced angiosarcoma two years prior, a 77-year-old female presented with dyspnea and bilateral pleural effusions. Diagnostic thoracentesis demonstrated findings consistent with metastatic angiosarcoma. Angiosarcoma of the breast is exceptionally rare among soft tissue neoplasms and is typically associated with a poor prognosis.
References
Grimer RJ. Size matters for sarcomas! Ann R Coll Surg Engl. 2006 Oct;88(6):519-24. doi: 10.1308/003588406X130651. PMID: 17059708; PMCID: PMC1963770.
Hillenbrand T, Menge F, Hohenberger P, Kasper B. Primary and secondary angiosarcomas: a comparative single-center analysis. Clin Sarcoma Res. 2015 May 23;5:14. doi: 10.1186/s13569-015-0028-9. PMID: 26413264; PMCID: PMC4582641.
Arora TK, Terracina KP, Soong J, Idowu MO, Takabe K. Primary and secondary angiosarcoma of the breast. Gland Surg. 2014 Feb;3(1):28-34. doi: 10.3978/j.issn.2227-684X.2013.12.03. PMID: 25083491; PMCID: PMC4115777.
Chesebro AL, Chikarmane SA, Gombos EC, Giardino AA. Radiation-Associated Angiosarcoma of the Breast: What the Radiologist Needs to Know. AJR Am J Roentgenol. 2016 Jul;207(1):217-25. doi: 10.2214/AJR.15.15888. Epub 2016 Apr 21. PMID: 27099969.
Cao J, Wang J, He C, Fang M. Angiosarcoma: a review of diagnosis and current treatment. Am J Cancer Res. 2019 Nov 1;9(11):2303-2313. PMID: 31815036; PMCID: PMC6895451.
Huang J, Mackillop WJ. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer. 2001 Jul 1;92(1):172-80. doi: 10.1002/1097-0142(20010701)92:1<172::aid-cncr1306>3.0.co;2-k. PMID: 11443624.
Kirova YM, Vilcoq JR, Asselain B, Sastre-Garau X, Fourquet A. Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review. Cancer. 2005 Aug 15;104(4):856-63. doi: 10.1002/cncr.21223. PMID: 15981282.
Yap J, Chuba PJ, Thomas R, Aref A, Lucas D, Severson RK, Hamre M. Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2002 Apr 1;52(5):1231-7. doi: 10.1016/s0360-3016(01)02799-7. PMID: 11955733.
Ran An, Xiao-Juan Men, Xi-Hao Ni, Wei-Tao Wang, Chang-Liang Wang. Angiosarcoma of the breast: A Review. https://www.sciencedirect.com/science/article/pii/S2405844024004444
Park C, Kim M, Kwak Y, Moon KC, Kim SH, Keam B, Kim YJ, Kim TM, Kim DW. Real-World Clinical Outcomes and Prognostic Factors for Patients with Advanced Angiosarcoma who Received Systemic Treatment. Cancer Res Treat. 2021 Oct;53(4):1195-1203. doi: 10.4143/crt.2020.1337. Epub 2021 Feb 1. PMID: 33540493; PMCID: PMC8524033.
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Copyright (c) 2026 Rayna Patel, Ayman Salih, Robert Jame, Aadil Maqsood, Zaid Noori, Youngsook Yoon (Author)
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