Profound Non-Randomness in Dinucleotide Arrangements within Ultra-Conserved Non-Coding Elements and the Human Genome.

Authors

  • Emily Crossley Department of Bioinformatics, Student
  • Larisa Fedorova
  • Oleh A. Mulyar
  • Shuhao Qiu
  • Ryan Freeman
  • Alexei Fedorov

DOI:

https://doi.org/10.46570/utjms-2024-1191

Keywords:

DNA structure, UCNE, UCE, inhomogeneity, Symposium

References

References

Dimitrieva, S., & Bucher, P. (2013). UCNEbase--a database of ultraconserved non-coding elements and genomic regulatory blocks. Nucleic Acids Res, 41(Database issue), D101-109. https://doi.org/10.1093/nar/gks1092

Fedorova, L., Mulyar, O. A., Lim, J., & Fedorov, A. (2022). Nucleotide Composition of Ultra-Conserved Elements Shows Excess of GpC and Depletion of GG and CC Dinucleotides. Genes (Basel), 13(11). https://doi.org/10.3390/genes13112053

Vologodskii, A., & Frank-Kamenetskii, M. D. (2018). DNA melting and energetics of the double helix. Physics of life reviews, 25, 1-21.

Svozil, D., Hobza, P., & Sponer, J. (2010). Comparison of intrinsic stacking energies of ten unique dinucleotide steps in A-RNA and B-DNA duplexes. Can we determine correct order of stability by quantumchemical calculations?. The Journal of Physical Chemistry B, 114(2), 1191-1203

Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, D. (2002). The human genome browser at UCSC. Genome Res, 12(6), 996-1006. https://doi.org/10.1101/gr.229102

Bechtel, J. M., Wittenschlaeger, T., Dwyer, T., Song, J., Arunachalam, S., Ramakrishnan, S. K., ... & Fedorov, A. (2008). Genomic mid-range inhomogeneity correlates with an abundance of RNA secondary structures. BMC genomics, 9, 1-14.

Fedorova, L., & Fedorov, A. (2011). Mid-range inhomogeneity of eukaryotic genomes. The Scientific World Journal, 11, 842-854.

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Published

2024-11-21

How to Cite

Emily Crossley, Fedorova, L., Mulyar, O. A., Qiu, S., Freeman, R., & Fedorov, A. (2024). Profound Non-Randomness in Dinucleotide Arrangements within Ultra-Conserved Non-Coding Elements and the Human Genome. Translation: The University of Toledo Journal of Medical Sciences, 13(S1). https://doi.org/10.46570/utjms-2024-1191

Issue

Vol. 13 No. S1 (2024): The 2024 Department of Neurosciences and Psychiatry Research Symposium

Section

Departments of Neuroscience and Psychiatry Research Symposium

License

Copyright (c) 2024 Emily Crossley, Larisa Fedorova, Oleh A. Mulyar, Shuhao Qiu, Ryan Freeman, Alexei Fedorov (Author)

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